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- Progress in Nucleic Acid Research and Molecular Biology, Volume 9
- Copyright Page
- List of Contributors
- Preface
- Abbreviations and Symbols
- Contents
- Contents of Previous Volumes
- Some Articles Planned for Future Volumes
- Chapter 1. The Role of Conformation in Chemical Mutagenesis
- Chapter 2. Polarographic Techniques in Nucleic Acid Research
- Chapter 3. RNA Polymerase and the Control of RNA Synthesis
- I. Introduction
- II. General Concepts of the Regulation of RNA Synthesis
- III. Purity and Physical Properties of RNA Polymerase Preparations
- IV. The Transcription Mechanism
- V. Selective Transcription
- VI. The Mechanism of RNA Chain Initiation
- VII. Termination Signals
- VIII. Inhibitors
- IX. Conclusions
- References
- Note Added in Proof
- Chapter 4. Radiation-Induced Alterations in the Structure of Deoxyribonucleic Acid and Their Biological Consequences
- I. Introduction
- II. Evidence Favoring the Idea That DNA Is an Important Macromolecular Target for Lethal Radiation Effects in Living Systems
- III. A General Survey of the Physical and Chemical Nature of Radiation- Induced Damage to DNA
- IV. Radiation Action on DNA Replication
- V. Radiation Effects on DNA Transcription and on the Biosynthesis of RNA
- VI. Biological Consequences Resulting from Radiation-Induced Damage to DNA
- VII. A Working Hypothesis
- References
- Chapter 5. Optical Rotatory Dispersion and Circular Dichroism of Nucleic Acids
- Chapter 6. The Specificity of Molecular Hybridization in Relation to Studies on Higher Organisms
- Chapter 7. Quantum-Mechanical Investigations of the Electronic Structure of Nucleic Acids and Their Constituents
- I. Introduction
- II. Types of Calculation
- III. Schematic Description of the Methods of Calculation
- IV. Problems Investigated
- V. Electronic Properties of the Purine and Pyrimidine Bases
- VI. Interbase Interactions
- VII. Problems in Radio- and Photobiology
- VIII. Electronic Factors in Mutagenesis
- IX. Conclusion
- References
- Chapter 8. The Chemical Modification of Nucleic Acids
- I. Introduction
- II. Possibilities of Chemical Modification in the Study of the Primary and Secondary Structures of Nucleic Acids
- III. Importance of the Chemical Modification Methods for Studies of Nucleic Acid Function
- IV. Reactions Used for the Chemical Modification of Nucleic Acids
- V. Modification of the Uracil Nucleus with Hydroxylamine
- VI. Modification of the Cytosine Nucleus with Hydroxylamine
- References
- Author Index
- Subject Index
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